Amherst is the most populated town in upstate New York, and an inner ring suburb of Buffalo. As of the 2010 census, the town had a total population of 122,366.

The second largest in area and the most populous suburb of Buffalo, New York, the town of Amherst encompasses the village of Williamsville as well as the hamlets of Eggertsville, Getzville, Snyder, Swormville, and East Amherst. The town is in the northern part of Erie County and borders a section of the Erie Canal.

Amherst is home to the north campus of the University at Buffalo, the graduate campus of Medaille College, a satellite campus of Bryant & Stratton College, and Daemen College.

In July 2010, CNNMoney ranked Amherst 42nd in a list of the Top 100 Best Places to Live in America. In 2012, CNNMoney.com ranked Amherst 50th. In 2011 and 2012, Amherst was selected as one of America's 100 Best Communities for Young People by America's Promise Alliance.